Bridge Recombination Directionality Simulator
IS110 Mechanism
Dual-loop RNA-guided DNA synaptic complex & catalytic directionality
↺ Reset
▶ Step Cycle
⬇ Export FASTA & Report
Active Synaptosome Architecture
State: 1/4 Top-Strand Cleavage
RuvC-like Catalytic Tetramer
Target DNA (5'→3')
Donor DNA (3'←5')
TBL (Target Loop)
DBL (Donor Loop)
TBL Loop (Target)
DBL Loop (Donor)
Target DNA
Donor DNA
Recombinase Subunits
Recombination Mode (Directionality)
Forward Insertion (IS110 Standard)
Reversible Inversion (Symmetric Loops)
Seamless Excision (Resolution Path)
Pre-Configured Synthetic Construct
IS110 Wild-Type Synaptosome
Synthetic Bi-stable Gene Switch
Optimized Cassette Integrator
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