Embryo Screening & Governance Simulator

Polygenic Risk Scores (PRS) vs Historic State Coercion Analysis

Expected Gain / Reduction -0.65 SD Disease risk standard deviation
Max Selection Shift +1.12 SD Theoretical upper limit ($N=\text{max}$)
Coercion Index 0% (Voluntary) Individual parental autonomy
Historic Coercive Eugenics (20th C.)
  • State-mandated sterilization & reproductive restrictions
  • Homogenizing national population target
  • Suppression of individual reproductive freedom
  • Zero parental choice or consent
Modern Embryo Selection (PGT-P)
  • Voluntary parental choice within private IVF
  • Diverse individual family preferences (heterogeneous)
  • Primary focus on severe disease risk reduction
  • Restricted by sibling trait variance limits

Simulation Analysis Output

Selected 5 embryos with variance $R^2 = $ 15% under Modern Parental Choice framework. Average population shift yields a net expected change of -0.65 SD.
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