Selection Objective Weights
Cognitive PRS Weight
+1.0
Cardiovascular Health Weight
+0.8
Autoimmune Risk Avoidance
+0.5
Height Preference Weight
+0.2
Cohort Top Choice Count
Top 1
Ancestry Reference Baseline
SIMULATED EMBRYO BATCH (10 CANDIDATES)
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PARETO FRONTIER: COGNITIVE VS PLEIOTROPIC RISK
MULTI-TRAIT RADAR: EMBRYO E1
Population & Trade-off Telemetry
Expected Cognitive Shift:
+0.00 SD
Pleiotropic Risk Shift:
+0.00 SD
Expected Accuracy Rate:
100%
Selected Cohort Index:
E1
PLEIOTROPIC GENETIC CORRELATION MATRIX
| Trait | Cognitive | Cardio | Autoimmune | Height |
|---|---|---|---|---|
| Cognitive | 1.00 | -0.15 | +0.32 | +0.12 |
| Cardio | -0.15 | 1.00 | +0.18 | -0.08 |
| Autoimmune | +0.32 | +0.18 | 1.00 | +0.05 |
| Height | +0.12 | -0.08 | +0.05 | 1.00 |
Ancestry Prediction Penalty:
PRS models derived primarily from European GWAS reference panels suffer severe predictive power decay in non-European ancestries due to allele frequency shift and linkage disequilibrium differences.