HIV Vaccine Epitope & bnAb Lineage Simulator

1. Multi-Stage Immunogen Regimen Designer Stage: Priming (Day 0)

STAGE 1: PRIME (Day 0)Active

Precursor targeting & UCA BCR recruitment

STAGE 2: SHEPHERD (Wk 8)Pending

CDRH3 length selection & steric mutation

STAGE 3: POLISH (Wk 16)Pending

Cross-clade breadth & glycan shield penetration

2. Germinal Center Somatic Hypermutation (SHM) Trajectory ● UCA Clones ● Mutating BCRs ★ bnAb Lineage

VRC01 UCA Precursor Pool

1 in 300,000

Active Clones: 0

Mean SHM Divergence

0.0%

0 nt sub / heavy chain

CD4bs Epitope Affinity (KD)

>100 µM

No mature binding

Global Neutralization Breadth

0.0%

Mean IC50: >50 µg/mL

3. Immunological Event & Mutation Telemetry

[SYSTEM INITIALIZED] Standing by for immunization protocol execution. Select a preset or configure custom regimen.

Global HIV-1 Pseudovirus Panel 0 / 24 Neutralized

Evaluated against 24 tier-2 global isolates across Clades A, B, C, D, and CRF01_AE:

Clade Breadth Radar (Tier 2/3)

Lineage Structural Metrics

CDRH3 Loop Steric Fit: Clash Prone (5-aa insertion)

N276 Glycan Accommodation: Blocked

Off-Target Immunodominance: 0% (Controlled)