24-Hour Pharmacokinetic & Intracellular Uptake Simulator
Dynamic Renal Clearance Threshold: 0.95 mmol/L
Serum Mg²⁺ Concentration
Intracellular / Tissue Partition
Renal Excretion Filtration Cutoff
RCT Meta-Analysis Efficacy & Trial Responder Odds
Analysis: Sleep Latency RCT Meta-Analysis
Predicted Responder Rate
Cohen's d: 0.54 (Mod)
64% Responder Rate
High probability of clinical response due to baseline dietary deficiency (<250 mg/d) paired with high bioavailable chelate.
Physiological Target Mechanism
GABA-A Agonism & Melatonin Synergism
Mg²⁺ acts as a natural NMDA receptor blocker and allosteric modulator of GABA-A receptors, reducing central nervous system hyperexcitability and facilitating sleep spindle onset.
Formulation Bioavailability & Clinical Tolerability Matrix
| Compound | Elemental % | Relative Abs | BBB Entry | GI Side Effects | Primary Clinical Trial Niche |
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