Clinical Regimen & Parameters
Per-Visit Completion Adherence
92%
Calibrated against pediatric well-child drop-off models
Split Dose Spacing Interval
3 Months
Measles Basic Reproduction (R₀)
15.0
Calculates community elimination threshold: 1 - 1/R₀ (93.3% - 94.4%)
Cohort Epidemiological Impact (1,000 Infants)
Combined MMR (2 Visits)
Herd Immunity Sustained (Low Outbreak Hazard)
Rt = 0.81
Cohort completion exceeds the 95% critical threshold for measles transmission interruption.
Full 3-Antigen Protection
84.6%
846 of 1,000 children
Measles Immunity Rate
92.0%
Target: ≥ 95.0%
Cumulative Child Vulnerability
180,000
Child-days susceptible
Total Clinical Injections
2,000
2 per completing child
Cohort Micro-State Grid (400 Sample Children)
Fully Immunized
Partial (Missed Doses)
Unprotected / Dropped Out
Susceptible Child-Days by Pathogen Timeline
Age 0 to 72 Months
Measles Susceptibility
Mumps Susceptibility
Rubella Susceptibility
Appointment Completion Attrition Curve
Compound Decay (P = pⁿ)
Scientific Schedule Comparison & Pathogen Gap Breakdown
Nature Evidence Model
| Evaluation Metric | Combined MMR (Standard) | Split Single-Antigen (Modeled) | Epidemiological Delta / Hazard |
|---|---|---|---|
| Clinical Appointments Required | 2 Visits | 6 Visits | +4 additional clinic encounters |
| Full 3-Disease Cohort Protection | 84.6% (846/1000) | 59.0% (590/1000) | -25.6% adherence drop-off |
| Measles Elimination Threshold (95%) | 92.0% (Near Threshold) | 92.0% (Dose 1) → 77.8% (Dose 2) | Substantial breach of herd immunity |
| Cumulative Child-Days Susceptible | 180,000 child-days | 585,000 child-days | +405,000 excess exposure days |
| Mumps / Rubella Protection Gap | Protected by Month 12 | Delayed to Months 15–18+ | Expanded 3–6 month unprotected window |