1. IVF Batch Parameters N = 8 embryos
8
3 (Low yield)
8 (Typical)
16 (Exceptional)
-0.25
Trade-off correlation between high cognitive scores and psychiatric risk (e.g. autism/bipolar spectrum pleiotropy).
2. Selection Objective Function
Weights
Monogenic Defect (BRCA/Cystic Fibrosis)
50%
R² = 95% (High penetrance)
Hard Filter / Heavy Penalty
Cardiovascular / Diabetes PRS
30%
R² ≈ 15% (Polygenic predictive variance)
Lower risk is better
Cognitive / Trait PRS
20%
R² ≈ 8% (Complex polygenic ceiling)
Higher score is preferred
Theoretical Max Order Stat E[Z_max|N]:
+1.42 σ
Realized Phenotypic Shift ΔG:
+0.42 σ
Bounded by ΔG = r_pgs · E[Z_max|N] · √(1 - F_inbreeding/2). Phenotypic gains collapse rapidly as predictive variance R² or cohort size N shrink.
Optimal Embryo
#4
Clear
Expected Gain (SD)
+0.42 σ
phenotype
PRS Variance (R²)
8.0%
ceiling
Pleiotropic Cost
Low Negative Cov.
IVF Embryo Cohort Multi-Trait Matrix
Click any embryo to inspect its full genetic breakdown and counterfactual outcomes
Selected
Defect
ℹ️