Nuclear Envelope Morphology & Strain Simulation
Passage: 15 / 30
Cellular Passage Cycle (Replicative Age)
15
Therapeutic Presets
Genotype & Splicing Mechanics
LMNA Exon 11 Splice Site
c.1824C>T Mutated
...GGC TGG AGT...
Cryptic 5' splice site activation creates 50aa internal truncation (lacks ZMPSTE24 cleavage site).
Splicing Modifier (ASO Concentration)
0%
Farnesyltransferase Inhibitor (FTI)
0%
CRISPR Base Correction Efficiency
0%
Progerin / Lamin-A Fraction
0.52
High envelope accumulation
Nuclear Dysmorphy Score
0.68
Circularity loss & blebbing strain
Nuclear Integrity
32%
Structural stiffness & DNA protection
Senescence Passage Ceiling
18.4 passages
Replicative capacity limit
Projected Median Survival
14.2 years
Untreated clinical baseline
Longitudinal Kinetic Insight & Molecular Rescue
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