Comparative Biomarker Toxicological Profile
Relative Exposure (% combustible cigarette benchmark)
* Data compiled from UK Health Security Agency (Public Health England), US CDC, and independent WHO toxicological assay reviews.
Population Dynamic Parameters
Adjust variables to test public health hypotheses
% of adult smokers switching annually
% youth non-smokers initiating vaping
Relative toxicological burden of e-cigs
Policy horizon years (10–30)
Baseline population smoking rate
Net QALYs Gained
+1,425,000
Quality-Adjusted Life Years saved across cohort
Prevented Smoking Deaths
340,000
Premature adult deaths avoided via cessation
Excess Vaping Harm Cases
18,000
Attributable health burden from non-smoker uptake
Policy Balance Verdict
Net Positive Harm Reduction Balance
Cessation benefits outweigh youth adoption risks
Epidemiological Flow & Cohort Transitions
100M Population Standard Model
Data Provenance & Epidemiological Baselines
Public Health England (UK HSA)
Established the landmark ~95% less harmful baseline for e-cigarettes compared to combustible tobacco based on comparative toxicological biomarker emissions.
US Centers for Disease Control (CDC)
Provides longitudinal youth tobacco survey data (NYTS) tracking e-cigarette initiation among never-smoking adolescents and dual-use dynamics.
World Health Organization (WHO)
Global adult tobacco surveillance data used to benchmark standard mortality risk factors, cardiovascular relative risks, and QALY valuation parameters.